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Your Healthcare Provider Has Selected SUSTOL to Protect You From Nausea and Vomiting due to Your Chemotherapy

Medicines like SUSTOL are called antiemetics and may help to prevent nausea and vomiting due to certain chemotherapy1
SUSTOL is different from other antiemetics—after being injected under the skin, it slowly releases medication to prevent nausea and vomiting2
Because SUSTOL slowly releases medication, just one injection can provide protection for a full 5 days. Not all antiemetic medicines may offer this same level of protection1,3,4
SUSTOL Connect™ Patient Services provides assistance answering insurance coverage and reimbursement questions. Call 1-855-SUSTOL-6 (1-855-787-8656) for more information
Patient Education Brochure
The brochure is a handy guide about SUSTOL based on information covered in this website. You can download a copy for yourself or for others who may want a printed version of this information.
View brochure

Approved Use

SUSTOL is a prescription medicine called an “antiemetic.” SUSTOL is used in adults to help prevent the nausea and vomiting that happens right away or later with certain anti-cancer medicines (chemotherapy).

Important Safety Information

Do not receive SUSTOL if you are allergic to granisetron, any of the ingredients in SUSTOL, or any other medicine of this type (5-HT3s) used to help prevent nausea and vomiting.

Injection site reactions may be serious and require medical care. Reactions include infections, bruising, swelling that is caused by blood that collects under the skin (hematoma), bleeding, pain, tenderness, and small bumps (nodules) at the injection site. Some reactions may occur 2 weeks or more after SUSTOL administration. Your risk of severe bruising and hematomas at the injection site is increased if you take a blood thinner medicine (anticoagulant or antiplatelet medicine). Get medical care right away if you have signs of an infection at the injection site or bleeding at the injection site that is severe or lasting more than 24 hours.

Stomach and intestinal problems, such as problems with bowel movement (constipation), may be serious. Tell your healthcare provider if you have constipation or your constipation worsens after you receive SUSTOL. Get medical care right away if you have pain or swelling in your stomach area (abdomen).

Serious allergic reactions have happened in people who received SUSTOL and who have had allergic reactions to other 5-HT3 medicines. These reactions may occur up to 7 days or longer following SUSTOL administration. Get emergency medical help right away if you have any signs or symptoms of a serious allergic reaction including hives, swollen face, breathing trouble, or chest pain.

Serotonin syndrome is a possible life-threatening problem that can happen when taking 5-HT3 medicines, especially when used with some medicines that treat depression and migraine headaches.

Before receiving SUSTOL, tell your healthcare provider about all of your medical conditions, including constipation, recent stomach-area (abdominal) surgery, kidney problems and about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Inform your doctor if you are pregnant or breastfeeding or plan to become pregnant or breastfeed.

The most common side effects of SUSTOL include: injection site reactions, constipation, fatigue, headache, diarrhea, stomach-area (abdominal) pain, trouble sleeping or falling asleep, indigestion, dizziness, weakness, and heartburn.

For more information about SUSTOL, talk to your doctor or see full Prescribing Information.

References:
  1. SUSTOL [package insert]. Heron Therapeutics, Inc., Redwood City, CA; August 2016.
  2. Ottoboni T, Gelder MS, O’Boyle E. Biochronomer™ technology and the development of APF530, a sustained release formulation of granisetron. J Exp Pharmacol. 2014;6:15-21.
  3. Aloxi [package insert]. Eisai Inc., Woodcliff Lake, NJ; December 2015.
  4. Navari RM. Management of chemotherapy-induced nausea and vomiting. Drugs. 2013;3:249-262.




Approved Use

SUSTOL is a prescription medicine called an “antiemetic.” SUSTOL is used in adults to help prevent the nausea and vomiting that happens right away or later with certain anti-cancer medicines (chemotherapy).

Important Safety Information

Do not receive SUSTOL if you are allergic to granisetron, any of the ingredients in SUSTOL, or any other medicine of this type (5-HT3s) used to help prevent nausea and vomiting.

Injection site reactions may be serious and require medical care. Reactions include infections, bruising, swelling that is caused by blood that collects under the skin (hematoma), bleeding, pain, tenderness, and small bumps (nodules) at the injection site. Some reactions may occur 2 weeks or more after SUSTOL administration. Your risk of severe bruising and hematomas at the injection site is increased if you take a blood thinner medicine (anticoagulant or antiplatelet medicine). Get medical care right away if you have signs of an infection at the injection site or bleeding at the injection site that is severe or lasting more than 24 hours.

Stomach and intestinal problems, such as problems with bowel movement (constipation), may be serious. Tell your healthcare provider if you have constipation or your constipation worsens after you receive SUSTOL. Get medical care right away if you have pain or swelling in your stomach area (abdomen).

Serious allergic reactions have happened in people who received SUSTOL and who have had allergic reactions to other 5-HT3 medicines. These reactions may occur up to 7 days or longer following SUSTOL administration. Get emergency medical help right away if you have any signs or symptoms of a serious allergic reaction including hives, swollen face, breathing trouble, or chest pain.

Serotonin syndrome is a possible life-threatening problem that can happen when taking 5-HT3 medicines, especially when used with some medicines that treat depression and migraine headaches.

Before receiving SUSTOL, tell your healthcare provider about all of your medical conditions, including constipation, recent stomach-area (abdominal) surgery, kidney problems and about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Inform your doctor if you are pregnant or breastfeeding or plan to become pregnant or breastfeed.

The most common side effects of SUSTOL include: injection site reactions, constipation, fatigue, headache, diarrhea, stomach-area (abdominal) pain, trouble sleeping or falling asleep, indigestion, dizziness, weakness, and heartburn.